HCID 18537656, compound → HCID 18537692, compound

HRID 2303920Notes

Reaction equation

HRID 2303920 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:9]1[CH:33]=[CH:32][C:12]([O:13][C:14]2[CH:15]=[CH:16][C:17]([N+:29]([O-])=O)=[C:18]([N:20]([CH3:28])[C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:19]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC=CC=1.C(OCC)(=O)C>[Pd].CCCCCC.C(OCC)(=O)C>[NH2:29][C:17]1[CH:16]=[CH:15][C:14]([O:13][C:12]2[CH:11]=[CH:10][C:9]([N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:33][CH:32]=2)=[CH:19][C:18]=1[N:20]([CH3:28])[C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24]

Participants

5

Reactant 2

HCID 18537656HCID 18537656, compoundHCID 21584019Toluene ethylacetate

Product 1

HCID 18537692HCID 18537692, compoundYield 100.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226206Ethyl acetate hexaneSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-{5-[4-(t-butoxycarbonyl-n-hexylamino)phenoxy]-2-nitrophenyl}-N-methylcarbamate (13.8 g), palladium on carbon (10%, 1.0 g) and toluene/ethyl acetate=1/1 (140 ml) and the reaction mixture was purified to give the title compound (13.1 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-b5ee701cd8fd409698e6883bcc8c06de
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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