Nitroethane → HCID 69848810, compound

HRID 2303965Notes

Reaction equation

HRID 2303965 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:7]1=[C:6]2[CH:17]=O.C([O-])(=O)C.[NH4+].[N+:24]([CH2:27][CH3:28])([O-:26])=[O:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:7]1=[C:6]2[CH:17]=[C:27]([N+:24]([O-:26])=[O:25])[CH3:28]

Participants

4

Reactant 3

HCID 6587NitroethaneHCID 517165Ammonium AcetateHCID 18462112HCID 18462112, compound

Product 1

HCID 69848810HCID 69848810, compound

Procedure

A stirred solution of 2-methoxy-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indole-11-carboxaldehyde and ammonium acetate in nitroethane is heated to 100° C. for 1 h, cooled to room temperature and partitioned between ethyl acetate and water. The combined organic extracts are washed (water, brine), dried (sodium sulfate) and concentrated in vacuo to give the product.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe combined organic extracts are washed (water, brine)
  3. dry with materialdried (sodium sulfate)
  4. concentrationconcentrated in vacuo
  5. customto give the product

Sources & evidence

ORD record
ord-eafdc232b983449f8989d2b4c930f894
Source dataset
uspto-grants-2002_08
Patent number
US06433175B1

Reaction notes

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