反应详情

m-Cyanobenzamide (2.92 g), sodium nitrite (2.76 g), and dimethyl sulfoxide (50 ml) were mixed and stirred vigorously at room temperature. To the mixture, methanesulfonic acid (3.95 g) was added dropwise over ten minutes, and further stirred vigorously for three hours. The solvent was removed under reduced pressure, and water (50 ml) was added to the residue. The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 2.57 g of m-cyanobenzoic acid (yield 88%). The obtained m-cyanobenzoic acid had a purity of 96%.

1. stirringfurther stirred vigorously for three hours
2. customThe solvent was removed under reduced pressure, and water (50 ml)
3. additionwas added to the residue
4. filtrationThe precipitated crystals were collected through filtration
5. washwashed with water
6. customdried