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7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride → 7-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride | HCID 22665676 | — |
| 反応物 | N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide | HCID 22665795 | — |
| 生成物 | 7-Methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide | HCID 86756458 | — |
反応手順
This compound was prepared from 200 mg of 7-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride and 210 mg of 30a using the procedure described for 58c. Yield: 110 mg; m.p. 175-176° C., (+)-FAB-MS: 544 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06432955B1 |
| 出典データセット | uspto-grants-2002_08 |
| ORD ID | ord-d14e76e413a84542b44bf7da20147099 |
| 出典メモ | uspto-grants-2002_08 |