Sulfuryl chloride → 2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

HRID 2304279Notes

Reaction equation

[O:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][NH:4][CH2:3][CH2:2]1.[S:12](Cl)([Cl:15])(=[O:14])=[O:13].C(N(C(C)C)C(C)C)C.COC1C=C2C(CCN(S(Cl)(=O)=O)C2)=CC=1>>[O:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][N:4]([S:12]([Cl:15])(=[O:14])=[O:13])[CH2:3][CH2:2]1

Participants

Reactant 4

HCID 24648Sulfuryl chloride

HCID 81531Diisopropylethylamine

HCID 218827752,3,4,5-Tetrahydro-1,4-benzoxazepine

HCID 226656767-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride

Product 1

HCID 226657772,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

Procedure

This compound was prepared from 1.5 g of 2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine, 0.81 mL of sulfuryl chloride and 1.8 mL of ethyl diisopropyl amine using the procedure described for 63f. Yield: 0.3 g (oil), EI-MS: 247 (M+).

Sources & evidence

ORD record: ord-832a4543316d4e4d9473096b5fb49a6b
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06432955B1

Reaction notes

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