HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2304296Generated: November 1, 2026
Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline
https://huagongshe.com/reaction/2304296
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 7-Methoxy-isoquinoline-N-oxide hydrochloride | HCID 22665683 | — |
| Product | 1-Chloro-7-methoxyisoquinoline | HCID 22250181 | — |
Reaction Steps
7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06432955B1 |
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| Source dataset | uspto-grants-2002_08 |
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| ORD ID | ord-3efc43c5009b47909fc38669bd0e214b |
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| Source note | uspto-grants-2002_08 |
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