Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline

HRID 2304296Notes

Reaction equation

HRID 2304296 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][N+:10]([O-])=[CH:11]2)=[CH:6][CH:5]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([O:3][CH3:2])[CH:13]=2)[CH:8]=[CH:9][N:10]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 226656837-Methoxy-isoquinoline-N-oxide hydrochloride

Product 1

HCID 222501811-Chloro-7-methoxyisoquinoline

Conditions

Temperature
90 °C

Procedure

7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo.

Workup

  1. customExcess of phosphoryl chloride was removed in vacuo
  2. washThe remaining white solid was washed with water
  3. filtrationfiltered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-3efc43c5009b47909fc38669bd0e214b
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

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