HRID2304330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc(OC)cc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1

HCID57174480

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CN[C@H](Cc1ccc(OC)cc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1.Cl

HCID69780541

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

0.150 g of {[2-{2-(S)-[(1-Amino-isoquinolin-6-ylmethyl)-carbamoyl]-pyrrolidine-1-yl}-1-(R)-(4-methoxybenzyl)-2-oxo-ethyl]-tert.-butoxycarbonyl-amino}-acetic acid ethyl ester were treated with 5 mL of HCl in dioxane (5M solution) and the mixture was stirred for 3 h at ambient temperature. The solvent was distilled off and the remaining white solid was washed with diethyl ether and dried. Yield 0.100 g (80%); (+)-APCI-MS: 534 (MH+).

WORKUP

后处理

distillationThe solvent was distilled off
washthe remaining white solid was washed with diethyl ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-069e866d497140f3935da05b15120cb5
来源数据集: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06432955B1
来源说明: uspto-grants-2002_08

反应 SMILES

[CH2:1]([O:3][C:4](=[O:46])[CH2:5][N:6]([C@H:14]([CH2:37][C:38]1[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=1)[C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:36])[NH:23][CH2:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[C:31]([NH2:35])=[N:30][CH:29]=[CH:28]2)=[O:16])C(OC(C)(C)C)=O)[CH3:2].[ClH:47]>O1CCOCC1>[ClH:47].[CH2:1]([O:3][C:4](=[O:46])[CH2:5][NH:6][C@H:14]([CH2:37][C:38]1[CH:39]=[CH:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=1)[C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:36])[NH:23][CH2:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[C:31]([NH2:35])=[N:30][CH:29]=[CH:28]2)=[O:16])[CH3:2]