Lithium Hydroxide → HCID 22867972, compound

HRID 2304338Notes

Reaction equation

HRID 2304338 reaction equation
C[O:2][C:3](=[O:17])[C@H:4]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Li+].[OH-].OS([O-])(=O)=O.[K+].ClCCl>CO.O>[CH3:16][S:13]([NH:12][C@H:4]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:17])=[O:2])(=[O:15])=[O:14]

Participants

7

Reactant 4

HCID 3939Lithium HydroxideHCID 6344DichloromethaneHCID 516920Potassium bisulfateHCID 53818679HCID 53818679, compound

Product 1

HCID 22867972HCID 22867972, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

A mixture of 2-(R)-methanesulfonylamino-3-phenyl-propionic acid methyl ester (0.90 g) and 0.10 g of LiOH in 10 mL of methanol and 1 mL of water was stirred for 16 h at ambient temperature. KHSO4 was added, the volatiles were pumped off followed by addition of water, extraction with dichloromethane and removal of the solvent. Yield: 0.70 g (83%) of the title compound as a colorless oil. (−)-APCI-MS: 242 ([M-H]−).

Sources & evidence

ORD record
ord-58d879f07b2c41689f4936e070eb3bcd
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

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