HCID 12020528, compound → HCID 12020532, compound

HRID 2304380Notes

Reaction equation

[S:1](=[O:30])(=[O:29])([O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@@H:18]3[C@H:9]([C@H:10]4[C@@:14]([CH2:16][CH2:17]3)([CH3:15])[C:13]([C:22](=[O:28])[NH:23][CH2:24]CCC)=[CH:12][CH2:11]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1)[NH2:2].S(=O)(=O)(OC1C=CC2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C=CC4)CCC=2C=1)N>>[S:1](=[O:29])(=[O:30])([O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@@H:18]3[C@H:9]([C@H:10]4[C@@:14]([CH2:16][CH2:17]3)([CH3:15])[C:13]([C:22](=[O:28])[NH:23][CH3:24])=[CH:12][CH2:11]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1)[NH2:2]

Participants

Reactant 2

HCID 12020528HCID 12020528, compound

HCID 131723439HCID 131723439, compound

Product 1

HCID 12020532HCID 12020532, compound

Procedure

In similar manners to those described for the synthesis of sulfamate 11a, compound 11g was prepared from compound 8. FAB-MS m/z 405 (M+H)+; 1H NMR (270 MHz, DMSO-d6) δ 0.91 (s, 3H, CH3), 1.03 (t, 3H, J=7.1 Hz, CH2CH3), 3.12 (m, 2H, CH2CH3), 6.36 (s, 1H, 16-CH), 6.97 (d, 1H, J=2.3 Hz, ArH), 7.01 (dd, 1H, J=2.3, 8.6 Hz, ArH), 7.33 (d, 1H, J=8.6 Hz, ArH), 7.75 (t, 1H, J=5.7 Hz, NHCH2), 7.89 (s, 2H, NH2).

Sources & evidence

ORD record: ord-d4f2fa6161d44b52a694dd4dae0e39fa
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06436918B1

Reaction notes

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