HCID 12019228, compound → HCID 12019232, compound

HRID 2304383Notes

Reaction equation

S(=O)(=O)(OC1C=CC2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](C(=O)NCCC)CC4)CCC=2C=1)N.[S:30](=[O:59])(=[O:58])([O:32][C:33]1[CH:50]=[CH:49][C:48]2[C@@H:47]3[C@H:38]([C@H:39]4[C@@:43]([CH2:45][CH2:46]3)([CH3:44])[C:42]([C:51](=[O:57])[NH:52][CH2:53][CH:54]([CH3:56])[CH3:55])=[CH:41][CH2:40]4)[CH2:37][CH2:36][C:35]=2[CH:34]=1)[NH2:31]>>[S:30](=[O:58])(=[O:59])([O:32][C:33]1[CH:50]=[CH:49][C:48]2[C@@H:47]3[C@H:38]([C@H:39]4[C@@:43]([CH2:45][CH2:46]3)([CH3:44])[C@@H:42]([C:51](=[O:57])[NH:52][CH2:53][CH:54]([CH3:56])[CH3:55])[CH2:41][CH2:40]4)[CH2:37][CH2:36][C:35]=2[CH:34]=1)[NH2:31]

Participants

Reactant 2

HCID 12019228HCID 12019228, compound

HCID 12020530HCID 12020530, compound

Product 1

HCID 12019232HCID 12019232, compound

Procedure

In similar manners to those described for the synthesis of compound 7, compound 29d was prepared from compound 11d. TOF-MS m/z 435 (M+H)+; 1H NMR (270 MHz, DMSO-d6) δ 0.60 (s, 3H, CH3), 0.84 (d, 6H, J=6.9 Hz, CH(CH3)2), 2.60-3.16 (m, 2H, NHCH2), 6.95 (d, 1H, J=2.3 Hz, ArH), 7.00 (dd, 1H, J=2.3, 8.6 Hz, ArH), 7.34 (d, 1H, J=8.6 Hz, ArH), 7.49 (brt, 1H, J=5.6 Hz, NHCH2), 7.84 (brs, 2H, NH2).

Sources & evidence

ORD record: ord-c17b10993f974bb4bab2e931fbdafbe1
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06436918B1

Reaction notes

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