反应详情

A solution of 0.68 g (5 mmol) of 4′-aminoacetophenone (Aldrich), 0.60 mL of 90% methyl pyruvate (Aldrich) and 0.05 g (0.25 mmol) of p-toluenesulfonic acid in ethanol was hydrogenated in the presence of a catalytic amount of 10% Pd/C at from 30 to 15 psi of hydrogen for 16 hours. The catalyst was removed by filtering the reaction mixture through Celite and the solvent was evaporated to provide the crude product. The product was purified by column chromatography (silica gel using 1:9 EtOAc/hexanes as the eluant) to provide the title compound.

1. customThe catalyst was removed
2. filtrationby filtering the reaction mixture through Celite
3. customthe solvent was evaporated
4. customto provide the crude product
5. customThe product was purified by column chromatography (silica gel using 1:9 EtOAc/hexanes as the eluant)