Malononitrile → HCID 178488016, compound

HRID 2304447Notes

Reaction equation

HRID 2304447 reaction equation
CO[C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([NH:10][N:11]=[C:12]([C:15]#[N:16])[C:13]#[N:14])[S:9][C:5]=2[CH:4]=1.[C:19](#N)CC#N.[OH2:24].[NH2:25][NH2:26]>C(O)C>[NH2:16][C:15]1[C:12](=[N:11][NH:10][C:8]2[S:9][C:5]3[CH:4]=[C:3]([O:24][CH3:19])[CH:18]=[CH:17][C:6]=3[N:7]=2)[C:13]([NH2:14])=[N:26][N:25]=1

Participants

5

Reactant 3

HCID 8010MalononitrileHCID 24654Hydrazine hydrate (1:1)HCID 14930588HCID 14930588, compound

Product 1

HCID 178488016HCID 178488016, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared using 2-[(6-methoxybenzothiazol-2-yl)hydrazono]-malononitrile (200 mg), which was derived from 2-amino-6-methoxybensothiazole (1.17 g) and malononitrile (0.82 g) as described in Example 8, and hydrazine hydrate (0.2 mL) in ethanol. Solids had not formed after heating the reaction at 40° C. for 2 hrs. The solution was allowed to cool to room temperature and concentrated. The product was obtained after column chromatography purification (80 mg, 35%).

Workup

  1. customThis compound was prepared
  2. customSolids had not formed
  3. temperatureafter heating
  4. customthe reaction at 40° C. for 2 hrs
  5. concentrationconcentrated
  6. customThe product was obtained
  7. customafter column chromatography purification (80 mg, 35%)

Sources & evidence

ORD record
ord-9b1081e61aea4a858da87841e2351c70
Source dataset
uspto-grants-2002_08
Patent number
US06436915B1

Reaction notes

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