Acrylonitrile → HCID 18435791, compound

HRID 2304570Notes

Reaction equation

HRID 2304570 reaction equation
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15](#[N:18])[CH:16]=[CH2:17]>CO>[C:15]([CH2:16][CH2:17][N:10]1[CH2:9][CH2:8][C:7]([C:13]#[N:14])([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:12][CH2:11]1)#[N:18]

Participants

4

Reactant 2

HCID 7855AcrylonitrileHCID 1811384-Piperidinecarbonitrile, 4-phenyl-

Product 1

HCID 18435791HCID 18435791, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Phenyl-4-cyanopiperidine (7 g, 37.6 mmol) and acrylonitrile (2.97 ml ,45.1 mmol) were stirred at room temperature in methanol (34 mL) for 18 hours monitoring the reaction by tlc until complete. The solvent was removed under vacuum and the residue chased with toluene (2x). This residual oil was used directly in the next step

Workup

  1. customthe reaction by tlc until complete
  2. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-beb951b551b444b18c61f2f2c202f217
Source dataset
uspto-grants-2002_08
Patent number
US06436962B1

Reaction notes

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