Acrylonitrile → HCID 18435791, compound

Participants

Reaction Steps

4-Phenyl-4-cyanopiperidine (7 g, 37.6 mmol) and acrylonitrile (2.97 ml ,45.1 mmol) were stirred at room temperature in methanol (34 mL) for 18 hours monitoring the reaction by tlc until complete. The solvent was removed under vacuum and the residue chased with toluene (2x). This residual oil was used directly in the next step

Provenance & Evidence