HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(3-pyridinyl)- | HCID 3024894 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride | HCID 13518884 | 80% |
Reaction Steps
[4-(4-Methoxyphenyl)-5-(3-pyridyl)-I,3-thiazol-2-yl]amine (200 mg) was dissolved in 1% methanol solution of hydrogen chloride (3.2 mL), and the solvent was evaporated. The crude crystalline was recrystallized from methanol-ethyl acetate to give the title compound (180 mg, yield 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06436966B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-13c24b961baf4383b40f79de26b556b2 |
| Source note | uspto-grants-2002_08 |