Hydrochloric Acid → [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride

HRID 2304601Notes

Reaction equation

HRID 2304601 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:20])[S:12][C:13]=2[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:5][CH:4]=1.[ClH:21]>CO>[ClH:21].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[C:11]([NH2:20])[S:12][C:13]=2[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 30248942-Thiazolamine, 4-(4-methoxyphenyl)-5-(3-pyridinyl)-

Product 1

HCID 13518884[4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochlorideYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

[4-(4-Methoxyphenyl)-5-(3-pyridyl)-I,3-thiazol-2-yl]amine (200 mg) was dissolved in 1% methanol solution of hydrogen chloride (3.2 mL), and the solvent was evaporated. The crude crystalline was recrystallized from methanol-ethyl acetate to give the title compound (180 mg, yield 80%).

Workup

  1. customthe solvent was evaporated
  2. customThe crude crystalline was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-13c24b961baf4383b40f79de26b556b2
Source dataset
uspto-grants-2002_08
Patent number
US06436966B1

Reaction notes

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