6-Methoxy-3-pyridinylamine → 2-(3-Methoxyphenyl)-N-{2-methoxy(5-pyridyl)}acetamide

HRID 2304643Notes

Reaction equation

HRID 2304643 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10](Cl)=[O:11])[CH:6]=[CH:7][CH:8]=1.[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[N:18][CH:19]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[N:18][CH:19]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 811216-Methoxy-3-pyridinylamineHCID 27332463-Methoxyphenylacetyl chloride

Product 1

HCID 234408662-(3-Methoxyphenyl)-N-{2-methoxy(5-pyridyl)}acetamideYield 99%

Procedure

The title compound was prepared as described in Example 1.A, using 3-methoxyphenylacetyl chloride (4.8 g, 26.0 mmol) and 5-amino-2-methoxypyridine (3.23 g, 26.0 mmol) to afford the title compound (7.0 g, 99% yield): ES-MS (m/z) 272.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-fd3b362028d64f7b8e5b1e191432e0c5
Source dataset
uspto-grants-2002_08
Patent number
US06436923B1

Reaction notes

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