HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Fluoro-3-(trifluoromethyl)benzoyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzoic acid | HCID 522268 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Fluoro-3-(trifluoromethyl)benzoyl Chloride | HCID 144253 | — |
Reaction Steps
1.5 g of 4-fluoro-3-trifluoromethylbenzoic acid, 0.65 ml of thionyl chloride and two drops of DMF are heated under reflux for 12 h in 17 ml of toluene and the mixture is subsequently concentrated and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06436999B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-f504874ff5b948518f1682fb01133fa0 |
| Source note | uspto-grants-2002_08 |