Thionyl Chloride → 4-Fluoro-3-(trifluoromethyl)benzoyl Chloride

HRID 2304697Notes

Reaction equation

HRID 2304697 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].S(Cl)([Cl:17])=O>CN(C=O)C.C1(C)C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:17])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12]

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 5222684-Fluoro-3-(trifluoromethyl)benzoic acid

Product 1

HCID 1442534-Fluoro-3-(trifluoromethyl)benzoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

1.5 g of 4-fluoro-3-trifluoromethylbenzoic acid, 0.65 ml of thionyl chloride and two drops of DMF are heated under reflux for 12 h in 17 ml of toluene and the mixture is subsequently concentrated and used without further purification.

Workup

  1. concentrationthe mixture is subsequently concentrated
  2. customused without further purification

Sources & evidence

ORD record
ord-f504874ff5b948518f1682fb01133fa0
Source dataset
uspto-grants-2002_08
Patent number
US06436999B1

Reaction notes

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