Hydrochloric Acid → HCID 178430591, compound

HRID 2304814Notes

Reaction equation

HRID 2304814 reaction equation
[C:1]([C:4]1[C:9]([CH3:10])=[C:8](Cl)[C:7]([CH3:12])=[CH:6][N:5]=1)([OH:3])=[O:2].C[O-:14].[Na+].Cl>>[C:1]([C:4]1[C:9]([CH3:10])=[C:8]([OH:14])[C:7]([CH3:12])=[CH:6][N:5]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 103134284-Chloro-3,5-dimethylpicolinic AcidHCID 10942334Sodium Methoxide

Product 1

HCID 178430591HCID 178430591, compoundYield 89%

Procedure

Starting with 2-carboxy-4-chloro-3,5-lutidine, a sodium methoxide nucleophilic substitution reaction was conducted as described above for 24 hours. The aqueous layer was acidified to pH 2.5 with concentrated Hydrochloric acid. The precipitate was filtered and washed with water and dried under vacuum at 50ℑ C. The 2-carboxy-4-hydroxy-3,5-lutidine product was obtained as a light brown solid in 89% yield.

Workup

  1. customas described above for 24 hours
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried under vacuum at 50ℑ C

Sources & evidence

ORD record
ord-5efc88bd421c4ccaad7ae2af1dd7150c
Source dataset
uspto-grants-2002_08
Patent number
US06437139B1

Reaction notes

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