反应详情

温度

35 °C

3-bromomethyl-7-(2,6-difluorobenzyl)-4,7-dihydro-5-isobutyryl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine (32 g), N,N-dimethylformamide (64 ml) and N-ethyldiisopropylamine (8.84 g) were mixed and treated dropwise with N-methylbenzylamine (8.29 g) with cooling on ice, and the reaction mixture was stirred at 30 to 40° C. for 5 hours. The reaction mixture was poured into a mixture of a solution of potassium carbonate (9.5 g) in water (320 ml) and diisopropylether (320 ml) and the reaction mixture was stirred at room temperature for 2 hours and then with cooling on ice for 1 hour, and the crystal precipitated was recovered by a filtration, washed with water (600 ml) and diusopropylether (160 ml), dried in vacuo at 50° C. for 4 hours to obtain the title compound (33.58 g, 97.9%).

1. temperaturewith cooling on ice
2. stirringthe reaction mixture was stirred at room temperature for 2 hours
3. temperaturewith cooling on ice for 1 hour
4. customthe crystal precipitated
5. filtrationwas recovered by a filtration
6. washwashed with water (600 ml) and diusopropylether (160 ml)
7. customdried in vacuo at 50° C. for 4 hours