反应详情

To a mixture of 1.10 g of 4-hydroxy-decanoic acid hex-3-enyl ester, 0.64 g pyridine and 0.1 g dimethylaminopyridine in 5 ml tetrahydrofuran was slowly added a solution of 1.10 g myristoyl chloride in 5 ml tetrahydrofuran. The mixture was stirred for 16 hours at room temperature. Water was then added and the mixture extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, 2N hydrochloric acid, water, dried over magnesium sulfate and evaporated to dryness. The residue was chromatographed on silica gel to give 1.81 g of a colorless liquid.

1. extractionthe mixture extracted with ethyl acetate
2. washThe organic layer was washed with saturated sodium bicarbonate, 2N hydrochloric acid, water
3. dry with materialdried over magnesium sulfate
4. customevaporated to dryness
5. customThe residue was chromatographed on silica gel