反应详情

33.8 g of pentafluoropyridine (0.2 mol) are dissolved in 500 ml of dimethylformamide, the solution is cooled to OC by means of a cryostat, and a solution of 53.3 g of potassium 4-benzyloxycarbonylphenoxide (0.2 mol) in 400 ml of dimethylformamide is then added dropwise over the course of 2 hours. After 24 hours at 0° C., the potassium salt has reacted. The dimethylformamide is then removed in a rotary evaporator, the residue is taken up in a little tetrahydrofuran, and the solution is filtered through a silica-gel column. The clear solution obtained is evaporated in a rotary evaporator until the reaction product precipitates out. The reaction product is then stirred in n-hexane, filtered off via a fluted filter and then dried for 48 hours under nitrogen at 40° C./10 mbar in a vacuum drying cabinet (yield: 91%).

1. temperaturethe solution is cooled to OC by means of a cryostat
2. customThe dimethylformamide is then removed in a rotary evaporator
3. filtrationthe solution is filtered through a silica-gel column
4. customThe clear solution obtained
5. customis evaporated in a rotary evaporator until the reaction product
6. customprecipitates out
7. filtrationfiltered off via
8. filtrationa fluted filter
9. customdried for 48 hours under nitrogen at 40° C./10 mbar in a vacuum
10. customdrying cabinet (yield: 91%)