HCID 18459276, compound → HCID 9806181, compound

HRID 2305015Notes

Reaction equation

HRID 2305015 reaction equation
C([O:8][NH:9][C:10](=[O:41])[C:11]([OH:40])([CH2:28][S:29]([C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:12][S:13]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)(=[O:15])=[O:14])C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[OH:8][NH:9][C:10](=[O:41])[C:11]([OH:40])([CH2:28][S:29]([C:32]1[CH:33]=[CH:34][C:35]([O:38][CH3:39])=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH2:12][S:13]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:18][CH:17]=1)(=[O:15])=[O:14]

Participants

5

Reactant 2

HCID 18459276HCID 18459276, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 9806181HCID 9806181, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N-benzyloxy-2-hydroxy-2-[(4-methoxybenzenesulfonyl)methyl]-3-(4-phenylbenzenesulfonyl)-propionamide (0.152 g), 10% palladium on carbon, and 50 mL of absolute ethanol is placed under 20 psi of hydrogen, and agitated overnight at ambient temperature. The mixture is filtered through a Celite pad, rinsing with ethanol and with ethyl acetate. Concentration of the filtrate affords the title compound.

Workup

  1. filtrationThe mixture is filtered through a Celite pad
  2. washrinsing with ethanol and with ethyl acetate

Sources & evidence

ORD record
ord-60ee97177b0945e7a78f1a0bab94a0e2
Source dataset
uspto-grants-2002_08
Patent number
US06437177B1

Reaction notes

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