反应详情

To a solution of (±)-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}phenylamine (110 mg, 0.27 mmol) in methylene chloride (3 ml) was added benzylisocyanate (0.17 ml, 1.36 mmol) at 5° C., and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with EtOAc, washed with 1N hydrochloric acid, water, saturated sodium hydrogencarbonate solution, water and brine, dried over magnesium sulfate, and evaporated in vacuo. The resulting solid was collected and washed with EtOAc-hexane to give (±)-1-benzyl-3-{3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}phenyl}urea (100.7 mg, 69%).

1. washwashed with 1N hydrochloric acid, water, saturated sodium hydrogencarbonate solution, water and brine
2. dry with materialdried over magnesium sulfate
3. customevaporated in vacuo
4. customThe resulting solid was collected
5. washwashed with EtOAc-hexane