3-Chloro-1-propanol → HCID 18431959, compound

HRID 2305250Notes

Reaction equation

HRID 2305250 reaction equation
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[Cl:7][CH2:8][CH2:9][CH2:10][OH:11]>>[Cl:7][CH2:8][CH2:9][C:10]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])=[O:11]

Participants

3

Reactant 2

HCID 123133-Chloro-1-propanolHCID 693643-Chloropropionyl chloride

Product 1

HCID 18431959HCID 18431959, compound

Conditions

Temperature
100 °C

Procedure

101.5 ml (129.6 g, 1.00 mol) of 3-chloropropionyl chloride are added dropwise over about 30 minutes, at 90° C., to 86.1 ml of 3-chloro-1-propanol (97.4 g, 1.00 mol). During the addition, spontaneous evolution of gas occurs, and the reaction temperature drops to about 70° C. When the addition is complete, the reaction mixture is again heated to 100° C. and stirred at this temperature for a further 30 minutes. After cooling, the resultant crude product is purified by distillation.

Workup

  1. additionDuring the addition, spontaneous evolution of gas
  2. customdrops to about 70° C
  3. additionWhen the addition
  4. temperatureAfter cooling
  5. distillationthe resultant crude product is purified by distillation

Sources & evidence

ORD record
ord-1c167152404349b3be13df9a3f81b2a5
Source dataset
uspto-grants-2002_08
Patent number
US06440328B1

Reaction notes

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