3-Chloro-1-propanol → HCID 18431959, compound

Participants

Reaction Conditions

Reaction Steps

101.5 ml (129.6 g, 1.00 mol) of 3-chloropropionyl chloride are added dropwise over about 30 minutes, at 90° C., to 86.1 ml of 3-chloro-1-propanol (97.4 g, 1.00 mol). During the addition, spontaneous evolution of gas occurs, and the reaction temperature drops to about 70° C. When the addition is complete, the reaction mixture is again heated to 100° C. and stirred at this temperature for a further 30 minutes. After cooling, the resultant crude product is purified by distillation.

Provenance & Evidence