反应详情

A mixture of 300 mmole of the above-prepared 3,5-dihydroxy-1-adamantanecarboxylic acid, 450 mmole of n-butanol, 15 mmole of sulfuric acid, and 900 ml of toluene was stirred under reflux of toluene for 5 hours. The reaction mixture was concentrated and was then subjected to column chromatography on a silica gel to yield n-butyl 3,5-dihydroxy-adamantanecarboxylate.

1. concentrationThe reaction mixture was concentrated