Hydrazine hydrate (1:1) → 3-(3-Pyridinyl)-1h-pyrazole-1-butanamine

HRID 2305299Notes

Reaction equation

HRID 2305299 reaction equation
O.NN.[N:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[N:11]=2)[CH:5]=1>C(O)C>[N:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[N:11]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 121166052-[4-[3-(3-Pyridinyl)-1h-pyrazol-1-yl]butyl]-1h-isoindole-1,3(2h)-dione

Product 1

HCID 98373083-(3-Pyridinyl)-1h-pyrazole-1-butanamineYield 68.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7 ml of hydrazine hydrate is added to a suspension containing 450 ml of ethanol and 22.33 g of the product of Stage A. The reaction medium is taken to reflux for 15 hours. The ethanol is evaporated off, the reaction mixture is agitated with 200 ml of ethyl acetate, washed with salt water, dried, filtered and concentrated. In this way 9.60 g of sought product is obtained.

Workup

  1. temperatureto reflux for 15 hours
  2. customThe ethanol is evaporated off
  3. washwashed with salt water
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-000ac88dcb7249579358cdfcc9eebcfd
Source dataset
uspto-grants-2002_08
Patent number
US06440941B1

Reaction notes

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