反应详情

A suspension of methyl 3-[4-benzyloxyphenyl)-2-ethoxypropanoate (3.7 g, 11.78 mmol; preparation 2) and 10% Pd-C (0.37 g) in ethyl acetate (50 mL) was stirred at 25° C. under 60 psi hydrogen pressure for 24 h. The catalyst was filtered and the solvent was evaporated under reduced pressure. The residue was chromatographed over silica gel using a mixture of ethyl acetate and pet. ether (2:8) as an eluent to afford the title compound (2.2 g, 84%) as an oil.

1. filtrationThe catalyst was filtered
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was chromatographed over silica gel using
4. additiona mixture of ethyl acetate and pet. ether (2:8) as an eluent