HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(Aminomethyl)Benzoic Acid | HCID 65526 | — |
| Reactant | Ethoxycarbonylphthalimide | HCID 22254400 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]benzoic acid | HCID 747553 | 77.9% |
Reaction Steps
A mixture of 10 g of 4-aminomethylbenzoic acid, 14.5 g of carbethoxyphthalimide, 9.2 ml of triethylamine and 140 ml of tetrahydrofuran is maintained for 72 hours at reflux temperature. The precipitate formed is isolated at room temperature; after washing with an aqueous acidic solution and drying, 14.5 g of product are obtained. M.p.=264° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06440956B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-e8d0dd511fcf4d2f8051009d86cb5b85 |
| Source note | uspto-grants-2002_08 |