HCID 86587979, compound → HCID 22707298, compound

HRID 2305337Notes

Reaction equation

HRID 2305337 reaction equation
O1CCCCC1[O:7][NH:8][C:9](=[O:31])[C:10]1[CH:15]=[CH:14][C:13]([S:16](=[O:21])(=[O:20])[N:17]([CH3:19])[CH3:18])=[CH:12][C:11]=1[NH:22][C:23]1[CH:28]=[CH:27][C:26]([I:29])=[CH:25][C:24]=1[Cl:30]>Cl.CO.C(O)C>[Cl:30][C:24]1[CH:25]=[C:26]([I:29])[CH:27]=[CH:28][C:23]=1[NH:22][C:11]1[CH:12]=[C:13]([S:16](=[O:21])(=[O:20])[N:17]([CH3:19])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:9]([NH:8][OH:7])=[O:31]

Participants

5

Reactant 1

HCID 86587979HCID 86587979, compound

Product 1

HCID 22707298HCID 22707298, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The compound 2-(2-chloro4-iodo-phenylamino)-4-dimethylsulfamoyl-benzoic acid O-(tetrahydro-2H-pyran-2-yl)-oxyamide is dissolved in an appropriate hydrogen chloride-saturated solvent like methanol or ethanol. Once homogeneous, the solution is concentrated in vacuo to give the desired product. The product may be triturated with an appropriate solvent like chloroform or dichloromethane if further purification is necessary.

Workup

  1. concentrationOnce homogeneous, the solution is concentrated in vacuo

Sources & evidence

ORD record
ord-1f83d1c0963e40d0bc040c01d00d9752
Source dataset
uspto-grants-2002_08
Patent number
US06440966B1

Reaction notes

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