HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18432756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 18432761 | HCID 18432761 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18432756 | HCID 18432756 | — |
Reaction Steps
Ethyl acetate (40 ml) saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperidin-4-ylcarbonyl]piperazine (2.60 g) in ethyl acetate (20 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 1-[1-(3-fluoro-4-pyridyl)piperidin-4-carbonyl]piperazine hydrochloride (2.45 g) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06440972B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-54d80beeec7f4b7685e4a5f13346c03a |
| Source note | uspto-grants-2002_08 |