Hydrochloric Acid → HCID 18432756, compound

HRID 2305359Notes

Reaction equation

HRID 2305359 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][C:24]=3[F:29])[CH2:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[F:29][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][C:23]=1[N:20]1[CH2:21][CH2:22][CH:17]([C:15]([N:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)=[O:16])[CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18432761HCID 18432761, compound

Product 1

HCID 18432756HCID 18432756, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Ethyl acetate (40 ml) saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperidin-4-ylcarbonyl]piperazine (2.60 g) in ethyl acetate (20 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 1-[1-(3-fluoro-4-pyridyl)piperidin-4-carbonyl]piperazine hydrochloride (2.45 g) as a solid.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-54d80beeec7f4b7685e4a5f13346c03a
Source dataset
uspto-grants-2002_08
Patent number
US06440972B1

Reaction notes

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