Hydrochloric Acid → HCID 15338474, compound

HRID 2305369Notes

Reaction equation

HRID 2305369 reaction equation
[NH2:1][CH:2]([CH:7]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:3]([O:5]C)=[O:4].Cl>>[NH2:1][CH:2]([CH:7]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18432805HCID 18432805, compound

Product 1

HCID 15338474HCID 15338474, compound

Conditions

Temperature
0 °C

Procedure

6.0 g (19.0 mmol) of methyl 2-amino-3,3-di(3-methoxyphenyl)propionate were refluxed in 140 ml of 6 normal hydrochloric acid for 6 hours. The mixture was then cooled to 0° C., and the precipitate was filtered off, washed with water and dried. The solid was then dissolved in 50 ml of ethanol, 20 ml of propene oxide were added and the mixture was refluxed for 30 minutes. After cooling, the precipitate was filtered off, washed with ethanol and dried. 2.20 g (38.4%) of a white powder of melting piont 168-173° C. were obtained.

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed with water
  3. customdried
  4. dissolutionThe solid was then dissolved in 50 ml of ethanol
  5. addition20 ml of propene oxide were added
  6. temperaturethe mixture was refluxed for 30 minutes
  7. temperatureAfter cooling
  8. filtrationthe precipitate was filtered off
  9. washwashed with ethanol
  10. customdried
  11. customof melting piont 168-173° C.
  12. customwere obtained

Sources & evidence

ORD record
ord-92ebdb6151204d809b71d74dacb6dc7f
Source dataset
uspto-grants-2002_08
Patent number
US06440975B1

Reaction notes

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