Acetic Acid → HCID 6138292, compound

HRID 2305398Notes

Reaction equation

HRID 2305398 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([SH:9])[N:3]=1.C(O)(=O)C.[OH:14][C:15]1[CH:22]=[C:21]([OH:23])[CH:20]=[CH:19][C:16]=1[CH:17]=O.O>CN(C=O)C>[OH:14][C:15]1[CH:22]=[C:21]([OH:23])[CH:20]=[CH:19][C:16]=1[CH:17]=[C:7]1[C:6](=[O:8])[NH:5][C:4](=[S:9])[NH:3][C:2]1=[O:1]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 72132,4-DihydroxybenzaldehydeHCID 178516656HCID 178516656, compound

Product 1

HCID 6138292HCID 6138292, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
80 °C

Procedure

To a solution of 0.144 9 (1 mmol) of 4,6-dihydroxy-2-mercaptopyrimidine and 2 ml of acetic acid in 2 ml of DMF was added a solution of 2,4-dihydroxybenzaldehyde (1 mmol) in 2 ml of DMF. The suspension was heated to 80° C. under nitrogen for 16 hours. Upon cooling to room temperature, the reaction was poured into water and the precipitate collected by filtration. The crude product was washed with water, and the solid boiled in methanol for 1 minute. Filtration provided 2.6 mg of product.

Workup

  1. temperatureUpon cooling to room temperature
  2. filtrationthe precipitate collected by filtration
  3. washThe crude product was washed with water
  4. filtrationFiltration

Sources & evidence

ORD record
ord-79d07be9208d4970bee7aa60926dfe42
Source dataset
uspto-grants-2002_08
Patent number
US06440985B1

Reaction notes

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