反应详情

A 5% mixture of madurahydroxylactone in glacial acetic acid is mixed with 2 mole equivalents of phenylhydrazine and boiled under reflux for 30 min. The reaction mixture is then left to stand at room temperature for about 12 hours. The red solid which has crystallized out is filtered off with suction, washed with glacial acetic acid and dried. The crude product is extracted with tetrahydrofuran (THF) in a Soxhlet. On cooling, the product crystallizes out and is filtered off with suction and dried. The yield is about 83% of theory.

1. temperatureunder reflux for 30 min
2. waitThe reaction mixture is then left
3. customThe red solid which has crystallized out
4. filtrationis filtered off with suction
5. washwashed with glacial acetic acid
6. customdried
7. extractionThe crude product is extracted with tetrahydrofuran (THF) in a Soxhlet
8. temperatureOn cooling
9. customthe product crystallizes out
10. filtrationis filtered off with suction
11. customdried