Potassium Hydroxide → HCID 135529036, compound

HRID 2305431Notes

Reaction equation

HRID 2305431 reaction equation
[C:1]1([N:7]2[C:16](=[O:17])[C:15]3[C:14]([O:18]C(=O)C)=[C:13]4[C:22]5[C:35]([CH:36]=[CH:37][C:12]4=[CH:11][C:10]=3[CH:9]=[N:8]2)=[C:34]([O:38][CH3:39])[C:33]2[C:32](=[O:40])[C:31]3[C:26](=[CH:27][C:28]([O:46]C(=O)C)=[C:29]([CH3:45])[C:30]=3[O:41]C(=O)C)[C:25](=[O:50])[C:24]=2[C:23]=5[O:51]C(=O)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CN(C)C=O>[C:1]1([N:7]2[C:16](=[O:17])[C:15]3[C:14]([OH:18])=[C:13]4[C:22]5[C:35]([CH:36]=[CH:37][C:12]4=[CH:11][C:10]=3[CH:9]=[N:8]2)=[C:34]([O:38][CH3:39])[C:33]2[C:32](=[O:40])[C:31]3[C:26](=[CH:27][C:28]([OH:46])=[C:29]([CH3:45])[C:30]=3[OH:41])[C:25](=[O:50])[C:24]=2[C:23]=5[OH:51])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18432655HCID 18432655, compound

Product 1

HCID 135529036HCID 135529036, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 112 mg (0.15 mmol) of the resulting intermediate 2-phenyl-10,12,15,16-tetraacetoxy-8-methoxy-11-methyl-9,14-dioxo-9,14-dihydronaphthaceno[1,2-g]phthalazin-1-one in 2.3 m of N,N-dimethylformamide is mixed, while cooling in ice, with 2.3 m of 1 M potassium hydroxide solution and stirred at room temperature for 2 hours. The product is precipitated as a red solid (78 mg) by acidification with aqueous citric acid. The yield is 93% of theory.

Workup

  1. customThe product is precipitated as a red solid (78 mg) by acidification with aqueous citric acid

Sources & evidence

ORD record
ord-6a50bf9c0b934c7ea96643343106e42c
Source dataset
uspto-grants-2002_08
Patent number
US06440968B1

Reaction notes

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