3-Amino-1,2-propanediol → HCID 18433015, compound

HRID 2305503Notes

Reaction equation

HRID 2305503 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:21]=[CH:20][C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[CH:13]=2)[CH:3]=1.[NH2:22][CH2:23][CH:24]([OH:27])[CH2:25][OH:26]>>[ClH:1].[CH:13]1[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=2[CH:20]=[CH:21][C:12]=1[C:4]1[CH:3]=[C:2]([NH:22][CH2:23][CH:24]([OH:27])[CH2:25][OH:26])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 18433039HCID 18433039, compound

Product 1

HCID 18433015HCID 18433015, compound

Procedure

The title compound, m.p. 210-230° C. and MS: m/e=348 (M+), was prepared from 4-chloro-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-quinoline and (RS)-3-amino-1,2-propandiol.

Sources & evidence

ORD record
ord-a36a1bff7dd14b6fa0ae3e5f1a4f174d
Source dataset
uspto-grants-2002_08
Patent number
US06440995B1

Reaction notes

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