3-Amino-1,2-propanediol → HCID 18433029, compound

HRID 2305526Notes

Reaction equation

HRID 2305526 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[CH:3]=1.[NH2:22][CH2:23][CH:24]([OH:27])[CH2:25][OH:26]>>[ClH:1].[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:3]=[C:2]([NH:22][CH2:23][CH:24]([OH:27])[CH2:25][OH:26])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 18433060HCID 18433060, compound

Product 1

HCID 18433029HCID 18433029, compound

Procedure

The title compound, m.p. 243-247° C., and MS: m/e=362 (M+), was prepared from 4-chloro-2-(4-trifluoromethyl-phenyl)-quinoline and (RS)-3-amino-1,2-propandiol.

Sources & evidence

ORD record
ord-7958817d44a241058cd8307d58f7fbed
Source dataset
uspto-grants-2002_08
Patent number
US06440995B1

Reaction notes

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