4-Bromotoluene → 4-Chloro-7-methyl-2-p-tolyl-quinoline

HRID 2305551Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH3:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.Br[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH3:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[CH:3]=1

Participants

Reactant 2

HCID 78054-Bromotoluene

HCID 123263344-Chloro-7-methylquinoline

Product 1

HCID 184330834-Chloro-7-methyl-2-p-tolyl-quinoline

Procedure

The title compound, m. p. 110-111 ° C., MS: m/e=267 (M+), was prepared from 4-chloro-7-methyl-quinoline and 4-bromotoluene.

Sources & evidence

ORD record: ord-057f8731a2dc49d8aa11a622f6d6540d
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06440995B1

Reaction notes

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