Potassium Carbonate → HCID 9898883, compound

HRID 2305596Notes

Reaction equation

HRID 2305596 reaction equation
Cl[C:2]1[C:7](Cl)=[C:6]([NH:9][C@@H:10]([CH3:13])[CH2:11][OH:12])[C:5](Cl)=[C:4](Cl)[N:3]=1.C(=O)([O-])[O-].[K+].[K+]>[Pd].C(O)C>[N:3]1[CH:4]=[CH:5][C:6]([NH:9][C@@H:10]([CH3:13])[CH2:11][OH:12])=[CH:7][CH:2]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 12114314HCID 12114314, compound

Product 1

HCID 9898883HCID 9898883, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (S)-2-(2,3,5,6-tetrachloro-pyridin-4-ylamino)-propan-1-ol (6 g), 10% palladium on carbon (3 g), potassium carbonate (14.3 g) and ethanol (110 ml) was stirred under an atmosphere of hydrogen for 24 h. The reaction mixture was filtered through Harbolite™ and the filtrate was concentrated under reduced pressure to give the title compound as a white solid (3.2 g).

Workup

  1. filtrationThe reaction mixture was filtered through Harbolite™
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ef9b205ff1d94388b437ffc09866be63
Source dataset
uspto-grants-2002_08
Patent number
US06441008B1

Reaction notes

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