Butylamine → HCID 22641099, compound

HRID 2305612Notes

Reaction equation

HRID 2305612 reaction equation
[CH3:1][C:2]1[C:3]([Se:16][C:17]#[C:18][C:19]2[CH:27]=[CH:26][C:22]([C:23]([OH:25])=O)=[CH:21][N:20]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.O[N:29]1[C:33]2C=C[CH:36]=[CH:37][C:32]=2N=N1.C1(N=C=NC2CCCCC2)CCCCC1.C(N)CCC>C1COCC1>[CH2:33]([NH:29][C:23](=[O:25])[C:22]1[CH:26]=[CH:27][C:19]([C:18]#[C:17][Se:16][C:3]2[C:2]([CH3:1])=[CH:11][C:10]3[C:9]([CH3:12])([CH3:13])[CH2:8][CH2:7][C:6]([CH3:14])([CH3:15])[C:5]=3[CH:4]=2)=[N:20][CH:21]=1)[CH2:32][CH2:37][CH3:36]

Participants

6

Reactant 4

HCID 8007ButylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 18433354HCID 18433354, compound

Product 1

HCID 22641099HCID 22641099, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 10, 300 mg (0.72 mmol) of 6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinic acid are reacted with 194 mg (1.45 mmol) of 1-hydroxybenzotriazole, 300 mg (1.45 mmol) of 1,3-dicyclohexylcarbodiimide and 63.5 mg (0.87 mmol) of butylamine in 20 ml of THF. After purification on a column of silica (ethyl acetate 20/heptane 80), 60 mg (17%) of a yellow solid are obtained. m.p.=172° C.

Workup

  1. customAfter purification on a column of silica (ethyl acetate 20/heptane 80), 60 mg (17%) of a yellow solid
  2. customare obtained

Sources & evidence

ORD record
ord-f6527ef303234552b27956d8bed524d1
Source dataset
uspto-grants-2002_08
Patent number
US06441010B2

Reaction notes

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