HCID 53745165, compound → HCID 54298779, compound

HRID 2305637Notes

Reaction equation

HRID 2305637 reaction equation
C(OC([C:8]1[C:9]([NH:22][CH3:23])=[C:10]([CH:19]=[CH:20][CH:21]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH3:23][NH:22][C:9]1[CH:8]=[CH:21][CH:20]=[CH:19][C:10]=1[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]

Participants

4

Reactant 1

HCID 53745165HCID 53745165, compound

Product 1

HCID 54298779HCID 54298779, compoundYield 101.4%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of methyl 4-(3-t-butoxycarbonyl-[-methyl]aminophenoxy)butyrate(0.2 g) in a mixture of dichloromethane(1 mL) and trifluoroacetic acid(1 mL) was kept at ambient temperature for 1 h and evaporated to dryness. The residue was treated with water and ethyl acetate and the mixture was stirred while making basic with potassium carbonate. The organic phase was separated, dried and evaporated to dryness to give the product (0.14 g), [m/e224, MH+].

Workup

  1. customevaporated to dryness
  2. additionThe residue was treated with water and ethyl acetate
  3. customThe organic phase was separated
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-3c17b775b23f4e5891cd80e5dcadf86d
Source dataset
uspto-grants-2002_08
Patent number
US06441012B1

Reaction notes

Loading…