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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 230567Generated: October 30, 2026

Ammonia → 7-nitro-1H-indole-2-carboxamide

https://huagongshe.com/reaction/230567

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
ReactantEthyl 7-nitro-1H-indole-2-carboxylateHCID 250407—
Product7-nitro-1H-indole-2-carboxamideHCID 47319698—

Reaction Conditions

Temperature50 °C

Reaction Steps

A suspension of 133 mg (0.57 mmol) of ethyl 7-nitroindole-2-carboxylate in 3.84 ml of 28% aqueous ammonia is heated at 50° C. for 18 h in a stoppered glass tube. The reaction medium is filtered over sintered glass. The yellow solid obtained is washed with water and with cyclohexane and then dried under vacuum. 70 mg of 7-nitro-1H-indole-2-carboxamide are obtained in the form of a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07566736B2
Source datasetuspto-grants-2009_07
ORD IDord-aa1ca6611c304af49a226cf2de84133b
Source noteuspto-grants-2009_07