Cyclohexylhydroxylamine → alpha-(4-Benzyloxyphenyl)-N-cyclohexylnitrone

HRID 2305806Notes

Reaction equation

HRID 2305806 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:17]1([NH:23][OH:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[N+:23]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[O-:24])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 72935CyclohexylhydroxylamineHCID 78109Benzaldehyde, 4-(phenylmethoxy)-

Product 1

HCID 86587911alpha-(4-Benzyloxyphenyl)-N-cyclohexylnitrone

Procedure

The title compound was prepared according to the procedure described in Example 42 using 4-benzyloxybenzaldehyde and N-cyclohexylhydroxylamine. The title compound was obtained in 81.2% yield as slightly yellowish solid, m.p. 129.0° C. (Rf=0.30 on a silica gel plate using hexanes:EtOAc, 1:1, v:v, as an eluant).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ff102cbda256458f852acf2713a9c579
Source dataset
uspto-grants-2002_08
Patent number
US06441032B1

Reaction notes

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