Methanol → HCID 18416841, compound

HRID 2305929Notes

Reaction equation

HRID 2305929 reaction equation
C([O:3][C:4]([C:6]1([S:26]([C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:31][CH:30]=2)(=[O:28])=[O:27])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.CO.[OH-].[Na+]>C1COCC1>[CH2:36]([O:35][C:32]1[CH:33]=[CH:34][C:29]([S:26]([C:6]2([C:4]([OH:5])=[O:3])[CH2:7][CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:14]=3)[CH2:10][CH2:11]2)(=[O:28])=[O:27])=[CH:30][CH:31]=1)[CH2:37][CH2:38][CH3:39]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 18416759HCID 18416759, compound

Product 1

HCID 18416841HCID 18416841, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(4-Butoxy-benzenesulfonyl)-1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4-butoxy-benzenesulfonyl)-1-(3-phenoxy-benzyl)-piperidine-4-carboxylic ethyl ester (10.7 g, 24 mmol) dissolved in THF.Methanol (75: 50 ml) and 10 N NaOH (20 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 5.0 g (76%); off white solid; MS: 524.3 (M+H)+

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-577f6899e778452a9b293d9682c0fa1b
Source dataset
uspto-grants-2002_08
Patent number
US06441023B1

Reaction notes

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