HCID 69967032, compound → HCID 69968615, compound

HRID 2305968Notes

Reaction equation

HRID 2305968 reaction equation
[CH:1]1([CH2:4][S:5]([C:8]2[CH:13]=[C:12]([O:14][C:15]3[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-])=O)=[CH:17][C:16]=3[CH3:25])[CH:11]=[CH:10][C:9]=2[OH:26])(=[O:7])=[O:6])[CH2:3][CH2:2]1>CO>[NH2:22][C:18]1[CH:17]=[C:16]([CH3:25])[C:15]([O:14][C:12]2[CH:11]=[CH:10][C:9]([OH:26])=[C:8]([S:5]([CH2:4][CH:1]3[CH2:2][CH2:3]3)(=[O:7])=[O:6])[CH:13]=2)=[C:20]([CH3:21])[CH:19]=1

Participants

3

Reactant 1

HCID 69967032HCID 69967032, compound

Product 1

HCID 69968615HCID 69968615, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-Amino-2,6-dimethyl-phenoxy)-2-cyclopropylmethanesulfonyl-phenol was prepared from 2-cyclopropylmethanesulfonyl-4-(2,6-dimethyl-4-nitro-phenoxy)-phenol according to a procedure analogous to that described in EXAMPLE 4, Step A. Methanol was used instead of ethanol as a co-solvent. Reaction mixture was hydrogenated for 3 hours. After the mixture was filtered through Celite® and concentrated, the title product of Step D was used in the next step without purification. MS (APCI−) Calc.: 347.4, Found: 346.0 (M−1).

Workup

  1. customReaction mixture
  2. filtrationAfter the mixture was filtered through Celite®
  3. concentrationconcentrated
  4. customthe title product of Step D was used in the next step without purification

Sources & evidence

ORD record
ord-59ba65a771594a48a27b36c28256c24f
Source dataset
uspto-grants-2002_08
Patent number
US06441015B2

Reaction notes

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