反应详情

To a cyclohexane (100 ml) solution of 2-(1-chloro-2,2,2-trifluoro-1-methylethyl)-1,3-difluoro-5-methoxybenzene (8.84 9, 32.2 mmol) was added 1.0 M hexane solution of trimethylaluminum (129 ml, 129 mmol) at room temperature and the mixture was stirred under reflux condition for 4 hours. Then, the reaction was quenched with 2 N-hydrochloride aqueous solution and the product was extracted with hexane which was dried over sodium sulfate, filtration and evaporation to furnish 7.9 g (97% yield) of the title compound as a colorless oil.

1. temperatureunder reflux condition for 4 hours
2. customThen, the reaction was quenched with 2 N-hydrochloride aqueous solution
3. extractionthe product was extracted with hexane which
4. dry with materialwas dried over sodium sulfate, filtration and evaporation