Cyclohexane → HCID 57762925, compound

HRID 230597Notes

Reaction equation

HRID 230597 reaction equation
[CH2:1]1CCCCC1.Cl[C:8]([C:14]1[C:19]([F:20])=[CH:18][C:17]([O:21][CH3:22])=[CH:16][C:15]=1[F:23])([CH3:13])[C:9]([F:12])([F:11])[F:10].C[Al](C)C>CCCCCC>[F:23][C:15]1[CH:16]=[C:17]([O:21][CH3:22])[CH:18]=[C:19]([F:20])[C:14]=1[C:8]([CH3:1])([CH3:13])[C:9]([F:12])([F:11])[F:10]

Participants

5

Reactant 3

HCID 8078CyclohexaneHCID 16682925TrimethylaluminumHCID 57762922HCID 57762922, compound

Product 1

HCID 57762925HCID 57762925, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a cyclohexane (100 ml) solution of 2-(1-chloro-2,2,2-trifluoro-1-methylethyl)-1,3-difluoro-5-methoxybenzene (8.84 9, 32.2 mmol) was added 1.0 M hexane solution of trimethylaluminum (129 ml, 129 mmol) at room temperature and the mixture was stirred under reflux condition for 4 hours. Then, the reaction was quenched with 2 N-hydrochloride aqueous solution and the product was extracted with hexane which was dried over sodium sulfate, filtration and evaporation to furnish 7.9 g (97% yield) of the title compound as a colorless oil.

Workup

  1. temperatureunder reflux condition for 4 hours
  2. customThen, the reaction was quenched with 2 N-hydrochloride aqueous solution
  3. extractionthe product was extracted with hexane which
  4. dry with materialwas dried over sodium sulfate, filtration and evaporation

Sources & evidence

ORD record
ord-1a96d7089d3843be8182b8b30523cdb3
Source dataset
uspto-grants-2009_07
Patent number
US07566739B2

Reaction notes

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